Dr. Harshad Lade

Career Highlights

• Investigated β-lactam resistance mechanisms and novel drug targets in MRSA.
• Conducted WGS and molecular epidemiology of MRSA clinical isolates.
• Correlated genotypes with phenotypes biofilm formation and phenol-soluble modulins (PSMs) production in S. aureus clinical isolates.
• Evaluated diagnostic panels BD Phoenix CPO Detect Panel for Carbapenemase producing Enterobacterales and Allplex Respiratory Panels 1,2,3 and BioFire FilmArray for respiratory infections.

Professional Experience

• 2018 – 2023 Post Doctor
  Department of Laboratory Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea
• 2014 – 2018 Assistant Professor (KU Full-time Research Professor)
  Department of Environmental Engineering, Konkuk University, Seoul, Korea
• 2013 – 2014 Post Doctor
  Department of Environmental Engineering, Konkuk University, Seoul, Korea
• 2010 – 2013 Dr. D. S. Kothari-Post Doctoral Fellow
  Department of Biochemistry, Shivaji University, Kolhapur, India

Awards and Honor

• UGC Dr. D. S. Kothari Postdoctoral Fellowship, Shivaji University Kolhapur, India (2010 – 2013)
• Brain Pool Assistant Professor, Konkuk University, Seoul, Korea (2014 – 2016)
• Fulltime Research Professor, Konkuk University, Seoul, Korea (2016 – 2018)

Research Focus

• Molecular basis of β-lactam resistance in methicillin-resistant S. aureus (MRSA)
• Identification of novel antibiotic targets
• Drug discovery- Virtual screening of antimicrobial drugs
• Discovery of antimicrobial peptides (AMPs)
• Biofilm inhibition

Publications (Selected)

• WGS and Molecular Epidemiology
• 1. Harshad Lade, Tae-Im Kim, Jung-Min Kim, Yong-Kyun Kim, Kibum Jeon, Hyun Soo Kim, Han-Sung Kim, Wonkeun Song, and Jae-Seok Kim. Complete genome analysis of representative methicillin-resistant Staphylococcus aureus clinical strains prevalent in Korea. Annals of Clinical Microbiology, 2025, 28(3).
• Antimicrobial Resistance and Infectious Diseases
• 2. Harshad Lade, Jae-Seok Kim. Molecular determinants of β-lactam resistance in methicillin-resistant Staphylococcus aureus: An updated review. Antibiotics, 2023. https://doi.org/10.3390/antibiotics12091362
• 3. Lade H, Chung SH, Lee Y, Joo H-S, Kim J-S. Genotypes of Staphylococcus aureus clinical isolates are associated with phenol-soluble modulin (PSM) production. Toxins, 2022; 14:556. https://doi.org/10.3390/toxins14080556
• 4. Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim. Molecular basis of non-β-lactam antibiotics resistance in Staphylococcus aureus. Antibiotics, 2022, 11:1378. https://doi.org/10.3390/antibiotics11101378
• 5. Harshad Lade, Jae-Seok Kim. Bacterial targets of antibiotics in methicillin-resistant Staphylococcus aureus. Antibiotics, 2021, 10(4), 398. https://doi.org/10.3390/antibiotics10040398
• 6. Harshad Lade, Joon Hyun Park, Sung Hee Chung, In Hee Kim, Jung-Min Kim, Hwang-Soo Joo, and Jae-Seok Kim. Biofilm formation by Staphylococcus aureus clinical isolates is differentially affected by glucose and sodium chloride supplemented culture media. Journal of Clinical Medicine, 2019, 8, 1853. https://doi.org/10.3390/jcm8111853
• Clinical Diagnosis
• 7. Harshad Lade, Seri Jeong, Kibum Jeon, Han-Sung Kim, Hyun Soo Kim, Wonkeun Song, and Jae-Seok Kim. Evaluation of the BD Phoenix CPO Detect panel for detection and classification of carbapenemase producing Enterobacterales. Antibiotics, 2023, 12(7), 1215. https://doi.org/10.3390/antibiotics12071215
• 8. Harshad Lade, Jung-Min Kim, Yousun Chung, Minje Han, Eun-Kyung Mo, and Jae-Seok Kim. Comparative evaluation of Allplex Respiratory Panels 1, 2, 3, and BioFire FilmArray Respiratory Panel for the detection of respiratory infections. Diagnostics, 2022, 12(1), 9. https://doi.org/10.3390/diagnostics12010009
• Biofilm Inhibition and Quorum Sensing Inhibition (QSI)
• 9. Harshad Lade, Diby Paul, Ji Hyang Kweon. Quorum quenching mediated approaches for control of membrane biofouling. International Journal of Biological Sciences, 2014, 10(5), 547–562. (IF: 8.2) 10.7150/ijbs.9028
• 10. Harshad Lade, Diby Paul, Ji Hyang Kweon. Isolation and molecular characterization of biofouling bacteria and profiling of quorum sensing signal molecules from membrane bioreactor activated sludge. International Journal of Molecular Sciences, 2014, 15(2), 2255–2273. (IF: 4.9) https://doi.org/10.3390/ijms15022255
• 11. Harshad Lade, Won Jung Song, Young Jae Yu, Jun Hee Ryu, G. Arthanareeswaran, Ji Hyang Kweon. Exploring the potential of curcumin for control of N-acyl homoserine lactone-mediated biofouling in membrane bioreactors for wastewater treatment. RSC Advances, 2017, 7, 16392–16400. (IF:3.9) https://doi.org/10.1039/C6RA28032C
• 12. Harshad Lade, Diby Paul, Ji Hyang Kweon, 2015. Combined effects of curcumin and (–)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. Journal of Microbiology and Biotechnology, 2015, 25(11), 1908–1919. (IF: 2.5) https://doi.org/10.4014/jmb.1506.06010