Biomaterials & Biomedical Applications
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Biomaterials & Biomedical Applications
Introduction:
At MIT-ADTU BIO, our research around biomaterials shapes future-ready tools for therapy and diagnostics. We work with engineered substances interacting with biological systems to support, reinforce or substitute damaged tissues. With growing polymer manipulation and biomedical prototyping expertise, our focus remains on real-world applications, academic clarity and outcome-led solutions.
Research Areas
Our work spans multiple bioengineering themes with a strong emphasis on functionality, experimentation and real-time impact:
- Biomaterials for Therapeutics and Diagnostics: We develop polymer-based micro and nanoparticles with cavity-filled designs that support sustained drug release and targeted imaging. These include hollow structures combined with ultrasound contrast agents, magnetic properties and drug delivery elements. The approach uses emulsion evaporation techniques and explores biodegradable polymer hybrids. Students and researchers actively assess their physicochemical profiles and in vivo relevance.
- 3D Printing for Prosthesis: Our teams use CAD software and 3D printing systems to design and model custom implants—ranging from dental fixtures to knee joints. Upcoming work includes bionic arm prototyping and clinical testing of next-gen prosthetics. This vertical enables learners to explore tailored implant design and function in a real clinical context.
- Medical Device Prototyping: We explore new-age diagnostic and assistive devices to aid clinicians and physicians. Projects include wireless stethoscopes, non-invasive blood glucose monitors, therapeutic colour-sensor devices for psoriasis, and orthopaedic solutions for clubfoot in children. Work on leukodepletion blood filter technology is also in progress. Several prototypes have earned national recognition at SIH and NIC; some are under incubation.
Achievements and Publications
- Sethu, N., Patil, N. & Vyas, R. A Portable Air Purification Device for Occupational Safety of Health Care Professionals. Aerosol Sci Eng (2025).
https://doi.org/10.1007/s41810-025-00317-0
- Provisional Indian Patent filed for Multi-Control Electric Wheelchair
- Provisional Indian Patent filed for Adjustable Clubfoot Corrective Splint
- Provisional Indian Patent filed for Voice-Assistive Wheelchair for Paraplegic Patients
Bioprocess Engineering & Downstream Process
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Bioprocess Engineering & Downstream Process
Introduction
Bioprocessing at MIT-ADTU BIO is centred on harnessing biological systems—living cells such as bacteria and fungi or components like enzymes and chloroplasts—to develop resource-efficient, environmentally aligned solutions. The focus lies in transforming raw substrates into high-value bio-based products while addressing sustainability goals through integrated waste treatment and downstream recovery.
Research Areas
Our portfolio spans a broad spectrum of applied bioengineering and sustainability-driven research
- Bioprocess Engineering: The lab supports experimental and applied research in microbial conversions for renewable energy, biosorption and environmental remediation. Projects include bioethanol and biodiesel production, degradation of dyes and plastics, bioadsorption techniques, and phytochemical extraction from plant sources. This includes optimising microbial conditions, processing plant-based materials, and refining by-product utilisation.
- Downstream Processing and Waste Valorisation: A critical phase post-fermentation, this includes purification workflows using distillation, centrifugation, membrane separation, reverse osmosis, and other unit operations. The focus is on efficient recovery, product purity, biomass recycling, and responsible waste disposal.
- Waste Management and Bioadsorption: Research explores the collection, treatment and safe disposal of solid, liquid and gaseous waste across industrial, agricultural and domestic systems. Topics include metal biosorption using banana peel, dye degradation, and biofiltration via plant biomass—prioritising cost-effective, replicable systems aligned with environmental norms.
Facilities and Infrastructure
The department is equipped with essential lab infrastructure to support fermentation studies, bioseparation techniques and plant-based extraction processes:
- UV-Spectrophotometer
- 5-litre laboratory fermentor
- Laminar airflow system
- COD and BOD digesters
- Soxhlet apparatus
Achievements and Publications
Patents
- Plastic Degrading Reactor for Sanitary Pad Waste Disposal – Renu Vyas, Nayana Patil, Madhura Chandrashekar, Pranav Deepak Pathak
- Device and Assay for Detection of Antibiotics in Industrial Effluents – Sreya K., Swaroop Mhasawade, Nacya Sethu, Chandrakant Tagad, Renu Vyas
- Fibre-Based, Low-Cost Reusable Packaging from Corncob – Sanjay L. Bhagat, Vyankatesh S. Bhagat, Pranav D. Pathak
Publications
- Vidyadhar V. Gedam, Anup Chahande, Pranay Raut, Pranav D. Pathak – Characterisation and potential of Java citronella biomass for bioethanol production – Int. J. Environment and Waste Management (2020)
- Sanjay Bhagat, Vidyadhar V. Gedam, Pranav D. Pathak – Adsorption/desorption of Cu(II) and Zn(II) using banana peel – Int. J. Chemical Reactor Engineering, 18(3), 2020
- Vidyadhar V. Gedam, Pranay Raut, Anup Chahande, Pranav D. Pathak – Removal of Congo Red Dye using activated teak leaf powder – Applied Water Science, 9:55, 2019
- Saurabh N. Joglekar, Pranav D. Pathak, Sachin A. Mandavgane, Bhaskar D. Kulkarni – Citrus waste biorefinery: environmental impacts and recommendations – Environmental Science and Pollution Research, 26(34), 2019
- Pranav D. Pathak, Sachin A. Mandavgane, Bhaskar D. Kulkarni – Value-Added Products from Guava Waste – In: Biorefinery Production Technologies for Chemicals and Energy, 2020
- Pranav D. Pathak, Saurabh N. Joglekar, Sachin A. Mandavgane, Bhaskar D. Kulkarni – Fruit Peel Waste Biorefinery and Sustainability Issues – In: Bioresource Utilisation and Management, 2020
- Pranav D. Pathak – Medicinal Properties of Fruit Peel Waste – In: Advances in Bioengineering, Springer, 2020
- Pranav D. Pathak, Vidyadhar V. Gedam, Sanjay L. Bhagat, Anup Chahande – Biorefineries: High Value-Added Products in Rural India – In: Techno-Societal 2018, Springer, 2020
- Lokesh Sharma, Shubhankar Gouraj, Pranit Raut, Chandrakant Tagad – Surface-modified paper-based sensor using Ag NPs – Environmental Technology, 2020
- Tahsin Bennur, Chandrakant Tagad, R. C. Aiyer, Atul Kulkarni, Smita Zinjarde – Optical detection of Ni2+ using gold nanoparticles – Optical Materials, 2019
- Vedashree Sirdeshmukh, Chandrakant Tagad, Renu Vyas, Anup Kale – Nanomaterial-Enabled Electrochemical Biosensors for Bacterial Pathogens – In: Advances in Bioengineering, Springer, 2020
Biosensors Research
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Biosensors Research
Introduction
Current diagnostic methods are complex, lab-bound, and require expert handling. In response, we focus on developing portable, cost-effective biosensors for point-of-care diagnostics using biomolecules like enzymes, antibodies, nucleic acids, and whole cells.
We also work on low-cost sensors for detecting environmental contaminants. Our research includes tools for identifying pathogens in food, water, and hospital settings, as well as clinical biomarkers and pollutants like antibiotics, pesticides, and heavy metals. Functional nanomaterials are developed in-house to build effective biosensors.
Research Areas
- Development of point-of-care biosensors using biomolecules
- Detection of pathogens, biomarkers, and environmental pollutants
- Synthesis of nanomaterials for sensitive and selective sensors
Achievements and Publications
Patent
- Device and Assay for Detection of Antibiotics in Industrial Effluents – Sreya K., Swaroop Mhasawade, Navya Sethu, Chandrakant Tagad, Renu Vyas. Application No. 201921037177
Publications
- Sethu, N., & Vyas, R. (2021). Design and development of advanced biosensing systems for the rapid detection of antibiotics. International Journal of Environmental Analytical Chemistry, 103(15), 3616–3633.
https://doi.org/10.1080/03067319.2021.1912330
- Lokesh Sharma, Shubhankar Gouraj, Pranit Raut, Chandrakant Tagad – Development of a surface-modified paper-based colorimetric sensor using synthesised Ag NPs-alginate composite – Environmental Technology , 2020
- Tahsin Bennur, Chandrakant Tagad, R. C. Aiyer, Atul Kulkarni, Smita Zinjarde – A sensitive and selective optical detection of Ni2+ based on gold nanoparticles synthesised using Nocardiopsis – Optical Materials , 2019
- Chandrakant Tagad, Hyo Hyun Seo, Rucha Tongaonkar, Yeong Wook Yu, Jeong Hun Lee, Medini Dingre, Atul Kulkarni, Hassan Fouad, Shafeeque Ahmed Ansari, Sang Hyun Moh – Green Synthesis of Silver Nanoparticles Using Panax Ginseng Root Extract for the Detection of Hg2+ – Sensors and Materials , 2017
- Vedashree Sirdeshmukh, Chandrakant Tagad, Renu Vyas, Anup Kale – Nanomaterial-Enabled Rapid Electrochemical Biosensors for Bacterial Pathogens – In: Advances in Bioengineering , Springer, 2020
Drug Discovery Research
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Drug Discovery Research
Introduction
Our research group explores biological problems related to diseases using next-generation sequencing, SNP analysis, and mutational analysis of genomes. We use academic and commercial software to analyse biological data, investigate drug targets, and identify novel compounds through homology modelling, docking, and molecular dynamics. We then use our cell culture facility to test the results of in silico studies on in vitro models. We also guide UG/PG student projects and offer doctoral supervision.
Research Areas
- Application of genome analysis techniques to study disease mechanisms
- Drug target identification using homology modelling, docking, and dynamics
- Molecular modelling of SARS-CoV-2 target proteins
- Protein-protein interaction (PPI) studies and inhibitor database development
- Molecular dynamics simulations to analyse PPI interface behaviour
Software and Computational Tools
- Bioinformatics: Schrödinger Maestro, MOE, AutoDock Vina, GLIDE, GROMACS, NAMD, CytoScape, VMD
- Chemoinformatics: ChemAxon Marvin Suite, ChemDraw, Screening Assistant
Achievements and Publications
Awards
- Best Paper Award – PPI2 Server: A webserver on protein-protein interaction inhibitors, International Conference on Recent Trends in Bioengineering, 1 February 2020
- Best Poster Award – Computational studies of novel chromone inhibitors on Src kinase family, 17 February 2019
- Best Paper Award – Chromone/aza-chromone fused α-aminophosphonates as Src kinase inhibitors, 16 February 2018
Publications
- Biswas, Rupam, et al. “Crystal structure and molecular dynamics simulation of Mycobacterium tuberculosis MaoC-like dehydratase HtdX provide insights into substrate binding and membrane interactions.” Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics (2025): 141082. Doi- https://doi.org/10.1016/j.bbapap.2025.141082
- Saha, Sagarika, Sanket Bapat, Durairaj Vijayasarathi, and Renu Vyas. “Exploring potential biomarkers and lead molecules in gastric cancer by network biology, drug repurposing and virtual screening strategies.” Molecular Diversity 29, no. 3 (2025): 2341-2366.
- Lokhande K.B., Doiphode S., Vyas R., Swamy K.V. –Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19 – J Biomol Struct
- Bapat S. – Modeling of protein complexes involved in signaling pathway for Non-Small Cell Lung Cancer, In: Vyas R. (Ed.), Advances in Bioengineering, Springer, 2019
- Bapat S., Vyas R., Karthikeyan M. – Exploring energy profiles of protein-protein interactions (PPIs) using DFT method – Letters in Drug Design & Discovery, 2019
- Bapat S., Vyas R., Karthikeyan M., Muthukrishnan M. – Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Chromone/Aza-Chromone Fused α-Aminophosphonates as Src Kinase Inhibitors – J Sci Ind Res (NISCAIR), 2019
- Bapat S. et al. – 2018 Index IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2019
- Nalla V., Shaikh A., Bapat S., Vyas R., Karthikeyan M., Yogeeswari P., Sriram D., Muthukrishnan M. – Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents – Royal Society Open Science, 2018
- Kotharkar N., Bapat S., Vyas R., Pathak Pranav, A Comparative Chemoinformatics Analysis of compounds extracted from Nyctanthes arbor-tristis, Combinatorial Chemistry & High Throughput Screening (2023); 26 DOI: 10.2174/1386207326666230417085141
- Shaikh N, Bapat S, Karthikeyan M, Vyas R. A Review on Computational Analysis of Big Data in Breast Cancer for Predicting Potential Biomarkers. Current Topics in Medicinal Chemistry.(2022);22 (21):1793-1810.
DOI: 10.2174/1568026622666220907121942
- Panchal R, Bapat S, Mukherjee S, Chowdhary A. In silico binding analysis of lutein and rosmarinic acid against envelope domain III protein of dengue virus. Indian J Pharmacol. (2021) Nov-Dec;53(6):471-479.
DOI: 10.4103/ijp.IJP_576_19
- Bapat, S. “Modeling of protein complexes involved in signaling pathway for Non-Small Cell Lung Cancer” (2019) In. Vyas, R. (Eds.) Advances in Bioengineering, Springer, ISBN: 978-981-15-2062-4
DOI: 10.1007/978-981-15-2063-1_1
- Nalla, V., Shaikh, A., Bapat, S., Vyas, R., Karthikeyan, M., Yogeeswari, P., Sriram, D. and Muthukrishnan, M., 2018. Identification of potent chromone embedded [1, 2, 3]-triazoles as novel anti-tubercular agents. Royal Society open science, 5(4), p.171750.
DOI: 10.1098/rsos.171750
Machine Learning & Artificial Intelligence
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Machine Learning & Artificial Intelligence
Introduction
Our research group works at the intersection of data and medical bioengineering using publicly available databases and advanced analytics. We apply machine learning (ML) and artificial intelligence (AI) to predict gene and protein function, with applications in disease diagnostics and healthcare.
Research Areas
- Application of ML in the detection and diagnosis of neurological diseases such as ADHD
- Use of machine learning models to predict cancer biomarkers
- Development of biological data repositories and integration with AI for healthcare inferences
Software and Computational Tools
- RapidMiner
- Eureqa Formulize
Achievements and Publications
Publications
- Sethu, Navya, and Renu Vyas. “Overview of machine learning methods in ADHD prediction.” In Advances in Bioengineering, pp. 51-71. Singapore: Springer Singapore, 2020.
Doi- https://doi.org/10.1007/978-981-15-2063-1_3
- Bhongale, M., Kaushal, P. and Vyas, R. (2024) ‘Automated COVID-19 detection from chest X-ray and CT images using optimized hybrid classifier’, Int. J. Biomedical Engineering and Technology, Vol. 45, No. 4, pp.269–295.
https://doi.org/10.1504/IJBET.2024.140559
- Bhongale, Madhavi, et al. "Patch-based U-NET model and MSqueezeNet-PyramidNet for efficient segmentation
and classification of tuberculosis, pneumonia, and COVID-19." Multimedia Tools and Applications (2025): 1-35.
Doi- https://doi.org/10.1007/s11042-025-20788-0
- Tiwary S., Naniwadekar M., Sonolikar R., Bapat S., Yerudkar A., Kamble S.P., Tambe S.S. – Prediction of Rate Constants of Photocatalytic Degradation of Pharmaceutical Pollutants by Artificial Intelligence based Genetic Programming Formalism – Current Environmental Engineering, 2018
- Vyas R., Bapat S., Karthikeyan M., Tambe S., Kulkarni B.D. – Application of Genetic Programming (GP) formalism for building disease predictive models from protein-protein interactions (PPI) data – IEEE/ACM Trans. on Computational Biology and Bioinformatics, 2016 [PMID: 28113781]
- Vyas R., Bapat S., Jain E., Karthikeyan M., Tambe S., Kulkarni B.D. – Building and analysis of protein-protein interactions related to diabetes mellitus using support vector machine, biomedical text mining and network analysis – Computational Biology and Chemistry, 65, 2016, pp. 37–44 [PMID: 27744173]
- Goel P., Bapat S., Vyas R., Tambe A., Tambe S.S. – Genetic programming-based quantitative structure–retention relationships for the prediction of Kovats retention indices – Journal of Chromatography A, 1420, 2015, pp. 98–109 [PMID: 26460075]
- Vyas R., Bapat S., Jain E., Tambe S., Karthikeyan M., Kulkarni B.D. – A study of machine learning-based classification methods for virtual screening of lead molecules – Combinatorial Chemistry & High Throughput Screening, 18(7), 2015, pp. 658–672 [PMID: 26138573]
- Wadapurkar, R., Bapat, S., Mahajan, R., & Vyas, R.. Machine learning approaches for prediction of ovarian cancer driver genes from mutational and network analysis. Data Technologies and Applications, (2023)
DOI: 10.1108/dta-03-2022-0096
- Nilofer Shaikh, Sanket Bapat, Muthukumarasamy Karthikeyan et al. Machine Learning Approaches for Identification of Potential Biomarkers from Cancer Omics Data, 28 October 2023, PREPRINT (Version 1) available at Research Square.
DOI: https://doi.org/10.21203/rs.3.rs-3480799/v1
Nanobiotech Research
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Nanobiotech Research
Introduction
The Nanobiotechnology group focuses on synthesising, characterising, and exploring nanomaterials for diverse applications in bioengineering. The lab aims to advance research and sustainable innovation in nanomaterials for healthcare and related biological systems. With expertise spanning nanomaterials, sensor technology, synthetic biology, and application biology, the team addresses both fundamental and applied challenges. From food packaging to advanced diagnostic tools, nanobiotechnology plays an increasingly vital role in society. The future of nanodevices, targeted drug delivery, and material design continues to offer wide potential.
Research Areas
- Nano synthesis and characterisation for bioengineering applications
- Use of nanomaterials in healthcare diagnostics, drug delivery, and sensor systems
Achievements and Publications
Publications
- Bala P., Kale S.N. – Smart Biopolymeric Nanocarriers for Drug Delivery Applications , Advances in Bioengineering , Springer, 2020
- Lokesh Sharma, Shubhankar Gouraj, Pranit Raut, Chandrakant Tagad – Development of a surface-modified paper-based colorimetric sensor using synthesised Ag NPs-alginate composite – Environmental Technology , 2020
- Bennur T., Tagad C., Aiyer R., Kulkarni A., Zinjarde S. – A sensitive and selective optical detection of Ni2+ based on gold nanoparticles synthesised using Nocardiopsis – Optical Materials , 2019
- Tagad C., Seo H.H., Tongaonkar R., Yu Y.W., Lee J.H., Dingre M., Kulkarni A., Fouad H., Ansari S.A., Moh S.H. – Green Synthesis of Silver Nanoparticles Using Panax Ginseng Root Extract for the Detection of Hg2+ – Sensors and Materials , 2017
- Patil N., Gade W.N., Deobagkar D.D. – Epigenetic modulation upon exposure of lung fibroblasts to TiO2 and ZnO nanoparticles: alterations in DNA methylation – Int. J. Nanomedicine , 2016 [PMID: 27660443]
Patents
- A Process of synthesising Curcumin-Silver nanoparticle conjugates and antimicrobial formulation thereof – Ref. No. 201621022758 – Sangeeta Kale, Rohini Kitture, Narendra Wagh, Preetam Bala
- Blower impeller and its method of manufacturing – Application No. 201921036524 – Sanjay Madhukarrao Niwding, Sanjay Laxman Bhagat, Anup Sanjay Niwding, Pranav Deepak Pathak
- Plastic Degrading Reactor for Sanitary Pad Waste Disposal – Renu Vyas, Nayana Patil, Madhura Chandrashekar, Pranav Deepak Pathak
- Device and Assay for Detection of Antibiotics in Industrial Effluents – Sreya Krishakumar, Swaroop Mhasawade, Navya Sethu, Chandrakant Tagad, Renu Vyas – Application No. 201921037177
Synthetic Biology Research
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Synthetic Biology Research
Introduction
Synthetic biology is an emerging multidisciplinary field that applies engineering principles to biological systems. It involves re-designing living systems to synthesise products not found in nature—targeted to serve human needs and environmental goals. The field intersects with computational modelling, circuit and system design, synthetic metagenomics, DNA synthesis, metabolic engineering, and more. Applications span medicine, agriculture, energy, and environmental remediation. At the institute, ongoing research includes designing and constructing genetic circuits capable of degrading polymers in sanitary napkins.
Research Areas
- Design and construction of genetic circuits for polymer degradation
Facilities and Infrastructure
- Gradient PCR machines
- 2D Proteomics setup
- Sterile room with laminar flow
- Electrophoresis chambers for DNA
- Floor shaker/incubator
- Gel documentation system
- Western trans-blotting apparatus
- Microplate reader
- Tabletop refrigerated centrifuges
- Refrigerated microcentrifuges
- Milli-Q water system
- Autoclave
- Ice machine
- -20˚C and -80˚C freezers
Achievements and Publications
Awards
- Received funding of ₹10 lakh from DBT, Government of India, to participate in iGEM 2019, Boston, USA
- Best Poster Award at iGEM All India Meet, Bhopal
- Bronze Medal at iGEM 2019, Boston, USA
Publications
- Nayana S. Shaiwale, D.D. Deobagkar, D.N. Deobagkar, S.K. Apte – DNA adenine hypomethylation leads to metabolic rewiring in Deinococcus radiodurans – Journal of Proteomics , 2015 [PMID: 26049032]
- Nayana Patil, B. Basu, D.D. Deobagkar, S.K. Apte, D.N. Deobagkar – Putative DNA modification methylase DR_C0020 of Deinococcus radiodurans is an atypical SAM dependent C-5 cytosine DNA methylase – BBA General Subjects , 2017 [PMID: 28038990]
- Chandrashekhar Angadi, S.M. Manjula, A.B. Basavaradder, C. Madhura, S.S. Patil – Identification of high-yielding lines in F7 generation recombinant inbred lines ( G. hirsutum × G. hirsutum ) – Environment & Ecology , 2017
- Madhura C., Basamma K., P.V. Kencjanagouder – Assessment of genetic variability and interrelationship among minicore collection of groundnut (Arachis hypogaea L.) – International Journal of Plant Sciences , 2012
Tissue Engineering Research
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Tissue Engineering Research
Introduction
The lab explores therapeutic potential and cellular responses to drug compounds and nanoparticle formulations. Core focus areas include anticancer evaluation, toxicity profiling, and protective assays. Research also supports in vitro disease modelling and biomarker discovery. Studies are conducted using both primary cells and established lines, with in vivo collaborations underway.
Research Areas
- Therapeutic compound evaluation – Testing novel drug candidates for anticancer activity using wound healing, migration, and cytotoxicity assays. Gene and protein expression profiling is also conducted on primary cells and established cell lines.
- Nanoparticle and drug toxicity testing – Using pharmaceutical expertise and a wide range of cell lines, the lab assesses the toxicity of nanoparticle formulations and drug compounds.
- Cell protection studies – Screening bioactive compounds for their ability to protect mammalian cells under chemotherapy, radiation, or cryopreservation. These studies aim to support adjunct therapies in cancer care.
- In vitro 3D disease models – Developing scaffold-based 3D models using biodegradable polymers to mimic in vivo environments. These are used to test and validate potential therapeutics.
- Biomarker identification – Collaborating with local hospitals, the lab analyses clinical samples to identify gene and protein markers that could support early disease detection.
Facilities and Infrastructure
- Biosafety cabinets for cell culture
- Freezers (-20˚C and -80˚C)
- Liquid nitrogen facility for cryopreservation
- CO₂ incubator
- Inverted Fluorescence microscope
- 2D gel electrophoresis system
- Milli-Q ultrapure water filter assembly
Services Offered
- Cytotoxicity and anticancer assays
- Toxicity testing of novel drugs
- Creation of cell lines with differential gene expression
- Cryopreservation and maintenance of biological samples
- Training in cell culture techniques
- Protein expression analysis using western blotting and 2D gel electrophoresis
Achievements and Publications
Publications
- Vidya Ramdas, Rashmi Talwar, Moloy Banerjee, Advait Arun Joshi, Amit Kumar Das, Deepak Sahebrao Walke, Prashant Borhade, Usha Dhayagude, Rajesh Loriya, Ganesh Gote, Apparao Bommakanti, Aruna Sivaram, Gautam Agarwal, Arnab Goswami et al. – Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate – J. Med. Chem., 2019 [PMID: 31710479]
- K. Limbkar, A. Dhenge, D.D. Jadhav, H.V. Thulasiram, V. Kale, L. Limaye – Oral feeding with polyunsaturated fatty acids fosters hematopoiesis and thrombopoiesis in healthy and bone marrow-transplanted mice – Prostaglandins Leukot Essent Fatty Acids, 2017 [PMID: 28570944]
- K. Limbkar, A. Dhenge, D.D. Jadhav, H.V. Thulasiram, V. Kale, L. Limaye – Data on the effect of oral feeding of Arachidonic acid or Docosahexaenoic acid on haematopoiesis in mice – Data Brief, 2017 [PMID: 28861453]
- A.C. Dhenge, K. Limbkar, S. Melinkeri, V.P. Kale, L.S. Limaye – Arachidonic acid and Docosahexaenoic acid enhance platelet formation from human apheresis-derived CD34(+) cells – Cell Cycle, 2017 [PMID: 28388313]
Environmental and Sustainable Engineering
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Environmental and Sustainable Engineering
Introduction
This research area combines life sciences, chemical sciences, physical sciences, mathematics, and engineering to address environmental challenges with a focus on long-term sustainability. The department is supported by faculty with domain expertise, industry collaborators, allied research networks, and a strong alumni base.
Research Areas
- Environmental chemistry and microbiology
- Waste management, including wastewater, solid waste, faecal sludge, and plastic waste
- Recycling and upcycling technologies focused on resource recovery
- Environmental laws, policies, sanitation, and hygiene
- Impact assessment and environmental sustainability
- Applications of SDGs and unit operations in engineering
- Renewable energy systems and sustainable technology development
Publications
- Deshmukh, Sharvari, Samruddhi Walaskar, Sunil Deokar, Anuja Rajendra Jadhav, and Pranav Deepak Pathak. “Carbon from plastic: Synthesis, characterization, and application in dye wastewater treatment.” Water Environment Research 97, no. 6 (2025): e70092.
Doi- https://doi.org/10.1002/wer.70092
- Jee, Seung-Cheol, Dong-hee Han, Min Kim, Kyung-Bin Bu, Jung-Suk Sung, and Avinash A. Kadam. “Montmorillonite modified with Fe3O4 and tannic acid for inhibition of S. aureus and MRSA biofilm formation.” Applied Clay Science 276 (2025): 107913.
Doi- https://doi.org/10.1016/j.clay.2025.107913
- Bu, Kyung-Bin, Min Kim, Jung-Suk Sung, and Avinash A. Kadam. “Halloysite nanotubes decorated with Fe3O4 nanoparticles and tannic acid for effective inhibition of E. coli biofilm.” ACS Applied Nano Materials 7, no. 1 (2023): 313-322.
Doi- https://pubs.acs.org/doi/10.1021/acsanm.3c04518
- Sharma, A., Kapoor, D., Gautam, S., Landi, M., Kandhol, N., Araniti, F., Ramakrishnan, M., Satish, L., Singh, V.P., Sharma, P. and Bhardwaj, R., 2022. Heavy metal induced regulation of plant biology: Recent insights. Physiologia Plantarum, 174(3), p.e13688.
Doi- https://doi.org/10.1111/ppl.13688
- Singh, A.D., Khanna, K., Kour, J., Dhiman, S., Bhardwaj, T., Devi, K., Sharma, N., Kumar, P., Kapoor, N., Sharma, P. and Arora, P., 2023. Critical review on biogeochemical dynamics of mercury (Hg) and its abatement strategies. Chemosphere, 319, p.137917.
Doi- https://doi.org/10.1016/j.chemosphere.2023.137917
- Deokar, Sunil K., Anuja R. Jadhav, Pranav D. Pathak, and Sachin A. Mandavgane. “Biochar from microwave pyrolysis of banana peel: Characterization and utilization for removal of benzoic and salicylic acid from aqueous solutions.” Biomass Conversion and Biorefinery 14, no. 21 (2024): 27671-27682.
Doi- https://doi.org/10.1007/s13399-022-03562-2
- Ranade, Yogita, Pranav Pathak, Madhura Chandrashekar, Anita Pardeshi, and Sujoy Saha. “Bioremediation of lambda cyhalothrin by Bacillus inaquosorum and Bacillus spizizenii isolated from surface of Thompson seedless grape berry.” Biologia 79, no. 3 (2024): 1015-1026.
Doi- https://doi.org/10.1007/s11756-024-01598-5
- Sudarsan, Jayaraman S., Shruti Vaishampayan, Vidyadhar V. Gedam, Vasudha D. Katare, and Pranav D. Pathak. “Sustainable resource management through carbon emissions inventorization: A case of the Indian construction industry.” Environmental Quality Management 33, no. 3 (2024): 467-476.
Doi- https://doi.org/10.1002/tqem.22138
- Sudarsan, Jayaraman S., Shruti Vaishampayan, Vidyadhar V. Gedam, Vasudha D. Katare, and Pranav D. Pathak. “Sustainable resource management through carbon emissions inventorization: A case of the Indian construction industry.” Environmental Quality Management 33, no. 3 (2024): 467-476.
Doi- 10.1504/IJEWM.2024.142502
- Fernandes, Sunita, Ayush Bhoj, Pranav Kulkarni, Purva Vaidya, Yogita Ranade, and Priyanka Sharma. “Biocontrol Activity of Endophytic Isolates Bacillus safensis and Pseudomonas lactis From Azadirachta indica Against the Pathogen Xanthomonas campestris pv. vesicatoria in Tomato Plants.” Biotechnology and Applied Biochemistry (2025).
Doi- https://doi.org/10.1002/bab.70023
- N Sethu, P Premchandra, SB Kolhe, MB Kulkarni, R Vyas. (2025) ‘An integrated microfluidic device driven by an automated system for precise detection of antibiotics in water’, Sensors and Actuators A: Physical, 388, p. 116474. doi: 10.1016/j.sna.2025.116474.
- N Sethu, S Krishnakumar, V Mitra, C Tagad, R Vyas. (2023) ‘Design and development of a novel colorimetric assay and a portable optical system for the detection of aminoglycoside antibiotics’, Sensors and Actuators Reports, 5, p. 100151. doi: 10.1016/j.snr.2023.100151.
Academic and Industry Integration
Students work on six-month research projects in partnership with leading industries—an opportunity to apply classroom concepts to real-world scenarios and gain exposure to on-ground environmental challenges.
Support for Innovation
The department actively encourages students to shape their ideas into scalable solutions, supported by the in-house incubation centre that nurtures early-stage innovations.
